Chapter 20 in
haematology (Non-Hodgkin lymphoma)summary
-Non-Hodgkin lymphomas are a large group of clonal lymphiod tumours.Appromixately 85% are of
B-cell origin and 15% derive from T or NK cells.
-Their clinical prestation
and natural history are more variable than hodgkin
lymphoma and can vary from very indolent disease subtypes though to rapidly
progressive subtypes that need urgent treatment .
-For many years clinicans have divided lymphomas into lowgrade and high-grade disease. This is
useful as low –grade disorder are typically slowly progressive,respond well to
chemothrapy but are vary difficult to cure,whereas high-grade lymophomas are
aggressive more often curable.
-Investigation is with
lymph node biopsy,blood tests and radiology. Immuohistochemistry of the lymph
node is valuable and cytogenetic analysis is performed in may cases.
-Clinial staging is performed as for hodgki lymphoma.
-Treatment for NHL are based on a variety
of chemotherapy regimes.Anti-CD20 antibodies are used in most cases of B cell
lymphomas and have markedly imroved the outlook.
From
book: Essentail Haematology A.V.HOFFBRAND,P.A.H.MOSS.6EDITION
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