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Haematolgy summary 20


Chapter 20 in haematology (Non-Hodgkin lymphoma)summary

-Non-Hodgkin lymphomas are a large group of clonal lymphiod tumours.Appromixately 85% are of B-cell origin and 15% derive from T or NK cells.

-Their clinical prestation and natural history are more variable than hodgkin lymphoma and can vary from very indolent disease subtypes though to rapidly progressive subtypes that need urgent treatment .

-For many years clinicans have divided lymphomas into lowgrade and high-grade disease. This is useful as low –grade disorder are typically slowly progressive,respond well to chemothrapy but are vary difficult to cure,whereas high-grade lymophomas are aggressive more often curable.

-Investigation is with lymph node biopsy,blood tests and radiology. Immuohistochemistry of the lymph node is valuable and cytogenetic analysis is performed in may cases.

-Clinial staging is performed as for hodgki lymphoma.

-Treatment for NHL  are based on a variety of chemotherapy regimes.Anti-CD20 antibodies are used in most cases of B cell lymphomas and have markedly imroved the outlook.

 

From book: Essentail Haematology A.V.HOFFBRAND,P.A.H.MOSS.6EDITION
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