Chapter 8 in Haematology
(Granulocytes and monocytes) summary
-Granulocytes include neutrophils (polymorphs),eosinophils and basophils.They are made in
the bone marrow under the control of a variety of growth factors and have a short lifspan in the blood stream
befor entring tissues.
-Phagocytes (neutrophils and
monocytes) are the
body's main defence against bacterial infection.Neutrophil leucocytosis
occurs in bacterial infection and in other types of inflammation.Neutropenia ,
if severe, predisposes to infection. It may be caused by bone marrow failure,
chemotherapy or radiotherapy drugs.
-Eosinophilia is most frequently caused by allergic diseases, including skin
diseases,parasitic infection or drugs. Ti can be caused by clonacal increase in
eosinophils termed chronic eosinophil leukamia or an idiopathic condtion, often
associted with tissue damage.
-Detects of function of
neutrophils and monocytes may affect their chemotaxis,
phagocytesis oe killing.
-Histocytes are tissue
macrophages derived from ciculation monocytes.They may form cloncal diseases called
Langerhans' cell histocytosis which affect single or multiple organs.
-The haemophagocytic syndrom involves destruction of red cells, granulocytes and platelets by tissue
macrophages.
-Lysosomal storage diseases
are caused by inherited defect in the enzymes responsible for breakdawn of
glycolipids.Gaucher's disease is caused by glucocerebrosidase deficiency and is
associated with accumulation of glycolipids in the reticuloendothelial system
with splenomegaly,pancytopenia and bone lesions causing the main clincal
manifestations
From book: Essentail Haematology
A.V.HOFFBRAND,P.A.H.MOSS.6EDITION
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