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Haematology summray 8


Chapter 8 in Haematology (Granulocytes and monocytes) summary

-Granulocytes include neutrophils (polymorphs),eosinophils and basophils.They are made in the bone marrow under the control of a variety of growth factors  and have a short lifspan in the blood stream befor entring tissues.

-Phagocytes (neutrophils and monocytes) are the  body's main defence against bacterial infection.Neutrophil leucocytosis occurs in bacterial infection and in other types of inflammation.Neutropenia , if severe, predisposes to infection. It may be caused by bone marrow failure, chemotherapy or radiotherapy drugs.

-Eosinophilia is most frequently caused by allergic diseases, including skin diseases,parasitic infection or drugs. Ti can be caused by clonacal increase in eosinophils termed chronic eosinophil leukamia or an idiopathic condtion, often associted with tissue damage.

-Detects of function of neutrophils and monocytes may affect their chemotaxis, phagocytesis oe killing.

-Histocytes are tissue macrophages derived from ciculation monocytes.They may form cloncal diseases called Langerhans' cell histocytosis which affect single or multiple organs.

-The haemophagocytic syndrom involves destruction of red cells, granulocytes and platelets by tissue macrophages.

-Lysosomal storage diseases are caused by inherited defect  in the enzymes responsible for breakdawn of glycolipids.Gaucher's disease is caused by glucocerebrosidase deficiency and is associated with accumulation of glycolipids in the reticuloendothelial system with splenomegaly,pancytopenia and bone lesions causing the main clincal manifestations  

سhils termed chronic eosinophilise in eosy allergic diseases, including skin diseases,parasitic infection or drugs. ti soccurs

  From book: Essentail Haematology A.V.HOFFBRAND,P.A.H.MOSS.6EDITION

 
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