Chapter 12 in Haematology
(Haematoloical malignancy: managment) summary
-Progress in the treatment of haemopoietic malignancies has been the result of
improvemnets in both supportive therapy and speicific tumour treatments.
-Supportive treatments often include: insertion of a central nevous
catheter;
Appropriate use of red cell and
platelet transfusions;
Early administration of drugs to traet
infection;Otimiziation of the blood coagulation system Drugs to reduce side
effects such as nausea or pain;Psychological support.
-Gram-positive
skin organisms
such as staphyloccus are common infections and often colonize central venous
catheters.
-Gram-Negative bacteria are usually derived from the gut and and can cause
severe septicemia.
-The use of air filters,handwashing and antibiotics can reduce
infection rates .
-Neutropenic patients who developa fever should be treated urgently with
broad-spectrum antibiotics.
-Herpes viruses are a common cause of infection in patients who are significantly
immunosuppressed.
-Fungal infections are a major clinical problem for
patients undergoing chemotherapy.antifungal drugs may be used for either
prevention or treatment of disease.
-A wide range of drugs is now available for the
treatment of haemopoietic malignancy:
Alkylating agents,antimetabolites,anthracyclines,folate
antagonists,signal transduction inhibitors,steroids,monoclonal antibodies;immune
modulators,proteasome inhibitors and inhibitors of mitosis.
From
book: Essentail Haematology A.V.HOFFBRAND,P.A.H.MOSS.6EDITION
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