Chapter 3 in
hematology ( Hypochromic anemia) summary
-
-Iron is
present in the body in haemoglobin,myoglobin, haemosiderin and ferritin , and
in iron-containing enzymes, transferrin is the main transport protien in blood
and hepcidin the main regular of iron absorption and iron relese from
macrophages.
- Iron Metabolism is regulated according to iron status by intracellular iron
regulatory protiens and by control of hepcidin synthesis.
-Iron Deficiency is the most common cause of anaemia throughout the world. The
surm ferritin, serum iron and saturation of the iron binding capacity are
reduced.
-In western countries, it is usually caused by haemorrhage from the
gastrointestinal or the female genital tract.dietary in take is important
particulary i underdeveloped countries.
-The red cells are hypochromic and microcytic. It is treated by oral or parenteral
iron and by treating, as far as possible, the underlying cause.
-Other ferquent causes of a hypochromic, microcytic anaemia are the anaemia
of chronic disorders, which occures in patients with chronic inflammatory or
malignant diseases, and alph or beta thalassaemia.less frequent causes include
sideroblastic anemia (some cases) and lead poisoning.
-Sideroblastic anaemia are chracterised by frequent ring
siderobalsts in the marrow.
The most frequent is sub-type of
myelodyplasia .
From
book: Essentail Haematology A.V.HOFFBRAND,P.A.H.MOSS.6EDITION
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