Chapter 11 in Haematology
(Haematological malignancy:aetiology and genetics) summary
-The haemopoietic malignancies are clonal diseases that derive from a single cell
in the marrow or peripheral lymphoid tissue which has undergone genetic
alteration.
-They represent approximately 7% of all mlignant
disease.
-inherited and envirmental factor both predispose to tumour development
but the relative contribution of these is usually unclear.
-infections (viral and bacterial),drugs, radiation and chemicals can all inrease
the risk of developing a haemopoietic malignancy.
-Haematological malignancies occur because of genetic alteration that lead to
increased activation oncogenes or decreased activity of tumour suppressor
genes.
-These genetic alterations may occur through avarity of mechanisms such as
point mutation, chromosomal, traslocation, or gene deletion .
-Important investigation include study of the chromosomes
(karyotype analysis),FISH,PCR, microtarry analysis,flow cytometry and
immunohistochmeistry.
-These investigations guide the diagnosis treatment and
moitoring for residual disease of individual cases.
From
book: Essentail Haematology A.V.HOFFBRAND,P.A.H.MOSS.6EDITION
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