Chapter 10 in Haematology
(spleen) summary
-The normal dult spleen wight 150*250g and is 5-13 cm in diameter. It has a
specialized circulation because the majority of arterioles end in
"cords" which lack an endothelial lining. The blood re-entres the
circulation via venous sinuses. The cords and sinuses form the red pulp which
monitors the inegrity of red blood cells.
-The central arterioles are surrounded by lynphoid tissue called white pulp which
is similar in structure to a lymph node.
-The spleen removes aged or abnormal red cells, and excess DNA ans siderotic
granules, from intact red cells. It also has a specialized immune function
against capsulated bacteria, pneumococcus,haemophilus influenza and
meningococcus to which splenectomy is needed for splenic rupture and in some
haematological diseases.
-Enlargement of the spleen
(splenomegaly) occurs in many amlignant and benign haematologicaldiseases,in portal
hypertension and with systemic diseases, including acute and chronic
infections.hyposplenism occurs in sickle cell anamia, gluten-induced
enteropathy and rarely in other diseases.
From
book: Essentail Haematology A.V.HOFFBRAND,P.A.H.MOSS.6EDITION
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