Chapter 5 in Haemtology (Macrocytic Anaemia) summary -Macrocytic anaemia show an increased size of circulating red cells (MCV>98 fl).Causes include vitamin B12 (B12,cobalamin) or folate deficiency,alcohol,liver disease, hypothyroidism,myelodysplasia, paraproteinneamia, and the neonatal period. - B12 or folate deficiency cause megaloblastic anaemia, in which the bone marrow erythroblast have a typical abnormal appearance. -B12 deficiency is usually caused by B12 malabsorption brought about by pericious anaemia in which there is autoimmune gastric, resulting in severe deficiency of intrinsic factor, a glycoprotien made in stomach which faciliates B12 absorption by the ileum. -Other gastrointestinal diseases as well as a vegan diet may cause B 12 deficiency . -folate deficiency may be caused by a poor diet ,malabsorption (e.g.gluten-induced enteropathy)or excess cell turnover(e.g.pregnancy,haemolytic anaemias, malignancy) -Treatment of B 12 defici...
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