Chapter 8 in Haematology (Granulocytes and monocytes) summary -Granulocytes include neutrophils (polymorphs),eosinophils and basophils.They are made in the bone marrow under the control of a variety of growth factors and have a short lifspan in the blood stream befor entring tissues. -Phagocytes (neutrophils and monocytes) are the body's main defence against bacterial infection.Neutrophil leucocytosis occurs in bacterial infection and in other types of inflammation.Neutropenia , if severe, predisposes to infection. It may be caused by bone marrow failure, chemotherapy or radiotherapy drugs. -Eosinophilia is most frequently caused by allergic diseases, including skin diseases,parasitic infection or drugs. Ti can be caused by clonacal increase in eosinophils termed chronic eosinophil leukamia or an idiopathic condtion, often associted with tissue damage. -Detects of function of neutrophils and monocytes may affect their chemotaxis, phagocytesis oe killing. ...
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